FEATURES

FAMILY

DESCRIPTION

Also known as STEA4_HUMAN, STEAP4, STAMP2, TNFAIP9. Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193). Homotrimer (PubMed:30337524). Interacts with PTK2/FAK1; the interaction may regulate PTK2 phosphorylation.

EXTERNAL LINKS

STEAP4

Mutations

Mutation(s) distribution

Mutations table