FEATURES

FAMILY

DESCRIPTION

Also known as UBC6_DEBHA, UBC6. Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.

EXTERNAL LINKS

uniprot
enzyme classification

UBC6

Ubiquitin-conjugating enzyme E2 6

UBC6

Structural Ligandability

Domains Chains

Distribution