FEATURES

FAMILY

DESCRIPTION

Also known as CENPQ_KLULA, OKP1. Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis (By similarity). Component of the inner kinetochore COMA subcomplex, which connects centromere-associated proteins and the outer kinetochore (PubMed:29046335). COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity). Through its multiple protein-protein interactions, OKP1 acts as a molecular nexus for inner kinetochore organization (PubMed:29046335). Component of the heterotetrameric kinetochore subcomplex COMA, which consists of AME1, CTF19, MCM21 and OKP1 (PubMed:29046335). The COMA subcomplex is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast) (By similarity). COMA binds the centromeric nucleosome-binding protein MIF2, and to the outer kinetochore MIND subcomplex. OKP1 interacts directly with AME1, with an NKP1-NKP2 dimer, and with CTF19-MCM21 (PubMed:29046335).

EXTERNAL LINKS

OKP1

Mutations

Mutation(s) distribution

Mutations table