FEATURES

FAMILY

DESCRIPTION

Also known as SPB4_KLULA, SPB4. ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. Component of pre-60S ribosomal complexes.

EXTERNAL LINKS

uniprot
enzyme classification

SPB4

ATP-dependent rRNA helicase SPB4

SPB4

Structural Ligandability

Domains Chains

Distribution