FEATURES

FAMILY

DESCRIPTION

Also known as MED17_KLULA, SRB4, MED17. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex.

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EXTERNAL LINKS

SRB4

Mediator of RNA polymerase II transcription subunit 17

ligandability Mutations

Molecular Synopsis
Structural Ligandability

SRB4

Structural Ligandability

Domains Chains

Distribution