FEATURES

FAMILY

DESCRIPTION

Also known as MED17_KLULA, SRB4, MED17. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex.

EXTERNAL LINKS

uniprot
enzyme classification

SRB4

Mediator of RNA polymerase II transcription subunit 17

Mutations

Mutation(s) distribution

Mutations table

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