FEATURES

FAMILY

DESCRIPTION

Also known as AUKBA_XENLA, aurkb-a, airk2-a. Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Phosphorylates 'Ser-10' of histone H3 during mitosis. Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts directly (via N-terminus and kinase domain) with incenp (via C terminus), and may weakly interact (via N-terminus) with birc5.1 to stabilize the complex. Interacts with mtus1.

EXTERNAL LINKS

aurkb-a

Aurora kinase B-A

aurkb-a

Molecular Synopsis