FEATURES

DESCRIPTION

Also known as SCAF8_MOUSE, Scaf8, Kiaa1116, Rbm16. Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation. Interacts with POLR2A; via C-terminal heptapeptide repeat domain (CTD) phosphorylated at 'Ser-2' and 'Ser-5' (PubMed:9528809). Identified in a complex with CDC5L and other spliceosomal proteins (By similarity).

EXTERNAL LINKS

Scaf8

SR-related and CTD-associated factor 8

Scaf8

Molecular Synopsis