FEATURES

FAMILY

DESCRIPTION

Also known as MRCKG_HUMAN, CDC42BPG, DMPK2. May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity).

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

CDC42BPG

Serine/threonine-protein kinase MRCK gamma

ligandability Mutations

CDC42BPG

Molecular Synopsis