FEATURES

FAMILY

DESCRIPTION

Also known as FAAH2_HUMAN, FAAH2, AMDD. Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z, 8Z, 11Z, 14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FAAH2

Fatty-acid amide hydrolase 2

Mutations

Mutation(s) distribution

Mutations table

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