FEATURES

FAMILY

DESCRIPTION

Also known as ST1C3_HUMAN, SULT1C3. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro phenols and hydroxypyrenes. Lithocholic acid appears to be the best substrate among the endogenous compounds tested and 3, 3', 5, 5'-tetrachloro-4, 4'-biphenyldiol shows the highest specific activity among the xenobiotic compounds., Exhibits weak sulphating activity and only toward chloro phenols (pentachlorophenol and 3, 3', 5, 5'-tetrachloro-4, 4'-biphenyldiol).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SULT1C3

Sulfotransferase 1C3

SULT1C3

Molecular Synopsis