FEATURES

FAMILY

DESCRIPTION

Also known as TRAF6_DANRE, traf6. E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Homotrimer. Homooligomer.

Also known as TRAF6_DANRE, traf6. E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, I ...

EXTERNAL LINKS

uniprot
enzyme classification

traf6

TNF receptor-associated factor 6

Structural Ligandability

Domains Chains

0 chains assessed

2 chains not associated with a domain

traf6

Structural Ligandability

Domains Chains

Distribution