FEATURES

FAMILY

DNA repair metallo-beta-lactamase (DRMBL) family

DESCRIPTION

Also known as DCR1A_HUMAN, DCLRE1A, KIAA0086, SNM1, SNM1A. May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DCLRE1A

DNA cross-link repair 1A protein

DCLRE1A

Molecular Synopsis