FEATURES

FAMILY

DESCRIPTION

Also known as ATAD2_HUMAN, ATAD2. May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ATAD2

ATPase family AAA domain-containing protein 2

ATAD2

Molecular Synopsis