FEATURES

FAMILY

DESCRIPTION

Also known as HPAH_ACIBA, C2-hpah. Oxygenase component of a two-component system that utilizes reduced FMN (FMNH2) supplied by the reductase component to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3, 4-dihydroxyphenylacetate (3, 4-DHPA). Also utilizes other reduced flavins such as FADH2 and reduced riboflavin to a lesser extent. Only the compounds with a hydroxyl group in the para (p-) position can be hydroxylated. May also oxidize phenol to catechol, and hydroxylate other phenol derivatives. Homotetramer. The p-hydroxyphenylacetate 3-hydroxylase (HpaH) is composed of an oxygenase component C2 and a reductase component C1.

EXTERNAL LINKS

C2-hpah

p-hydroxyphenylacetate 3-hydroxylase, oxygenase component

Mutations

Mutation(s) distribution

Mutations table

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