FEATURES

DESCRIPTION

Also known as CLC2A_HUMAN, CLEC2A, KACL. Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. Homodimer; non disulfide-linked. Interacts with KLRB1. Interacts with KLRF2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CLEC2A

Mutations

Mutation(s) distribution

Mutations table