FEATURES

FAMILY

DESCRIPTION

Also known as DPP8_HUMAN, DPP8, DPRP1. Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396) (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:29967349, PubMed:32796818). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DPP8

Dipeptidyl peptidase 8

DPP8

Molecular Synopsis