FEATURES

FAMILY

DESCRIPTION

Also known as IL34_HUMAN, IL34, C16orf77. Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Homodimer. Interacts with CSF1R.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IL34

Mutations

Mutation(s) distribution

Mutations table