FEATURES

FAMILY

DESCRIPTION

Also known as FMNL3_MOUSE, Fmnl3, Frl2, Kiaa2014. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. Interacts with SRGAP2 (via SH3 domain).

EXTERNAL LINKS

uniprot
enzyme classification

Fmnl3

Mutations

Mutation(s) distribution

Mutations table