FEATURES

FAMILY

DESCRIPTION

Also known as H32_HUMAN, H3C15, H3C14, H3C13, HIST2H3A, H3F2, H3FM, HIST2H3C, HIST2H3D. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer. Interacts with DNAJC9, CHAF1A and CHAF1B (PubMed:33857403).

Also known as H32_HUMAN, H3C15, H3C14, H3C13, HIST2H3A, H3F2, H3FM, HIST2H3C, HIST2H3D. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility ...

EXTERNAL LINKS

H3C15, H3C14, H3C13

Mutations

Mutation(s) distribution

Mutations table