FEATURES

FAMILY

DESCRIPTION

Also known as MED19_ASHGO, ROX3, MED19. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Component of the Mediator complex.

EXTERNAL LINKS

uniprot
enzyme classification

ROX3

Mediator of RNA polymerase II transcription subunit 19

ROX3

Structural Ligandability

Domains Chains

Distribution