FEATURES

FAMILY

DESCRIPTION

Also known as IF4E_ASHGO, TIF45. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

TIF45

Eukaryotic translation initiation factor 4E

TIF45

Structural Ligandability

Domains Chains

Distribution