FEATURES

FAMILY

DESCRIPTION

Also known as MMAA4_MYCTU, mmaA4, hma, mma4. Involved in the biosynthesis of hydroxymycolate, a common precursor of oxygenated mycolic acids (methoxy-mycolate and keto-mycolate). Probably transfers a methyl group from the S-adenosylmethionine (SAM) cofactor and, subsequently or simultaneously, a water molecule onto the double bound of ethylene substrates, leading to the formation of the hydroxylated product at the distal position. Involved in the activation of the antitubercular drug thiacetazone (TAC). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

mmaA4

Hydroxymycolate synthase MmaA4

mmaA4

Molecular Synopsis