FEATURES

FAMILY

flavoprotein pyridine nucleotide cytochrome reductase family

DESCRIPTION

Also known as NB5R4_HUMAN, CYB5R4, NCB5OR. NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CYB5R4

Cytochrome b5 reductase 4

CYB5R4

Molecular Synopsis