FEATURES

FAMILY

DESCRIPTION

Also known as CP51_TRYCC, CYP51. Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4, 4'-dimethyl cholesta-8, 14, 24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24, 25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.

EXTERNAL LINKS

uniprot
enzyme classification

CYP51

Sterol 14-alpha demethylase

CYP51

Molecular Synopsis