FEATURES

DESCRIPTION

Also known as RBBP6_HUMAN, RBBP6, P2PR, PACT, RBQ1. E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359)., (Microbial infection) [Isoform 1]: restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. Interacts with p53/TP53 and RB1 (By similarity). Interacts also with MDM2 and YBX1 (PubMed:17470788). Interacts also with MDM2 and YBX1 (PubMed:18851979). Interacts with NEK6 (PubMed:20873783). Interacts with ZBTB38 (PubMed:24726359).

Also known as RBBP6_HUMAN, RBBP6, P2PR, PACT, RBQ1. E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a r ...

EXTERNAL LINKS

RBBP6

E3 ubiquitin-protein ligase RBBP6

RBBP6

Molecular Synopsis