FEATURES

FAMILY

DESCRIPTION

Also known as SCD5_HUMAN, SCD5, ACOD4, SCD2, SCD4. Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828). May self-associate and form homodimers.

EXTERNAL LINKS

SCD5

Stearoyl-CoA desaturase 5

SCD5

Molecular Synopsis