FEATURES

FAMILY

DESCRIPTION

Also known as URP2_HUMAN, FERMT3, KIND3, MIG2B, URP2. Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity)., Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails).

Also known as URP2_HUMAN, FERMT3, KIND3, MIG2B, URP2. Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (IT ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FERMT3

Mutations

Mutation(s) distribution

Mutations table