FEATURES

DESCRIPTION

Also known as CIR1_HUMAN, CIR1, CIR. May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. Interacts with RP9, SNW1, SFRS1, SFRS2, U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex. Interacts with NKAPL (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CIR1

Mutations

Mutation(s) distribution

Mutations table