FEATURES

FAMILY

DESCRIPTION

Also known as HEXSF_BACTN, BT_1596. Exosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS). 2-O-sulfatase active on unsaturated non-reducing end hexuronate units. Has a slight preference for HS-derived structures (PubMed:25002587). GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).

EXTERNAL LINKS

uniprot
enzyme classification

BT_1596

Delta 4, 5-hexuronate-2-O-sulfatase

BT_1596

Molecular Synopsis