FEATURES

FAMILY

DESCRIPTION

Also known as GANAB_MOUSE, Ganab, G2an, Kiaa0088. Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1, 3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:27462106). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:28375157). Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH) (PubMed:9148925, PubMed:10921916, PubMed:27462106). Binds glycosylated PTPRC (PubMed:9148925, PubMed:10921916).

EXTERNAL LINKS

uniprot
enzyme classification

Ganab

Mutations

Mutation(s) distribution

Mutations table