FEATURES

FAMILY

DESCRIPTION

Also known as A311_LOXLA, A311. Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity). This toxin acts on sphingomyelin (SM) with high activity (PubMed:12419302, PubMed:14732720). It also act on acyl- and alkyl-lysophosphatidylcholine (LPC), but not on sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC) (PubMed:14732720). It may also act on ceramide phosphoethanolamine (CPE), and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity). It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity). Induces complement-dependent hemolysis and dermonecrosis (PubMed:12419302). Also induces increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).

EXTERNAL LINKS

A311

Dermonecrotic toxin LlSicTox-alphaIII1i

A311

Molecular Synopsis