FEATURES

FAMILY

DESCRIPTION

Also known as PLM3_PLAF7, PMIII, HAP. During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) or globins (PubMed:16624575). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable). Probable homodimer; in the zymogen form (Probable). Monomer; in the active form (PubMed:20435072). Acidification disrupts homodimerization (By similarity). Component of the hemozoin formation complex (HFC) composed of falcipain 2, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN (PubMed:23471987). The HFC complex is involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage (PubMed:23471987).

EXTERNAL LINKS

PMIII

Plasmepsin III

PMIII

Molecular Synopsis