FEATURES

FAMILY

DESCRIPTION

Also known as I2BP1_HUMAN, IRF2BP1. Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IRF2BP1

Interferon regulatory factor 2-binding protein 1

IRF2BP1

Molecular Synopsis