FEATURES

FAMILY

DESCRIPTION

Also known as RIOX2_HUMAN, RIOX2, MDIG, MINA, MINA53, NO52. Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Also known as RIOX2_HUMAN, RIOX2, MDIG, MINA, MINA53, NO52. Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RIOX2

Ribosomal oxygenase 2

RIOX2

Molecular Synopsis