FEATURES

FAMILY

DESCRIPTION

Also known as APLF_HUMAN, APLF, C2orf13, PALF, XIP1. Nuclease involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150). Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721). Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721, PubMed:23689425). Interacts with LIG4 (PubMed:17396150). Interacts with PARP1 (PubMed:17396150, PubMed:17353262). Interacts with XRCC4 (PubMed:17396150, PubMed:17353262, PubMed:18077224). Interacts (via KBM motif) with XRCC5 and XRCC6; promoting recruitment to DNA damage sites (PubMed:17396150, PubMed:17353262, PubMed:23689425). Interacts with XRCC1 (PubMed:17353262, PubMed:17507382).

Also known as APLF_HUMAN, APLF, C2orf13, PALF, XIP1. Nuclease involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150). Recruited to sites of DNA damage thr ...

EXTERNAL LINKS

APLF

Mutations

Mutation(s) distribution

Mutations table