FEATURES

FAMILY

DESCRIPTION

Also known as MIRO1_HUMAN, RHOT1, ARHT1. Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (PubMed:16630562). Interacts with ARMCX1 (By similarity). Found in a complex with KIF5B, OGT, RHOT2 and TRAK1 (PubMed:24995978).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RHOT1

Mutations

Mutation(s) distribution

Mutations table