FEATURES

FAMILY

DESCRIPTION

Also known as RPAP2_HUMAN, RPAP2, C1orf82. Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RPAP2

Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

RPAP2

Molecular Synopsis