FEATURES

FAMILY

PA-phosphatase related phosphoesterase family

DESCRIPTION

Also known as PLPP6_HUMAN, PLPP6, PPAPDC2. Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLPP6

Phospholipid phosphatase 6

PLPP6

Molecular Synopsis