FEATURES

FAMILY

Classic translation factor GTPase family

DESCRIPTION

Also known as ERF3B_HUMAN, GSPT2, ERF3B. Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Interacts with ETF1 (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with UPF1 and PABPC1.

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EXTERNAL LINKS

GSPT2

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

ligandability Mutations

GSPT2

Molecular Synopsis