FEATURES

DESCRIPTION

Also known as AN13A_HUMAN, ANKRD13A, ANKRD13. Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Interacts (via the UIM 3 and 4 repeats) with EGFR (ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ANKRD13A

Ankyrin repeat domain-containing protein 13A

ANKRD13A

Molecular Synopsis