FEATURES

FAMILY

DESCRIPTION

Also known as AGRG5_HUMAN, ADGRG5, GPR114, PGR27. Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ADGRG5

Adhesion G-protein coupled receptor G5

Mutations

Mutation(s) distribution

Mutations table

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