FEATURES

FAMILY

DESCRIPTION

Also known as KASM_ARATH, KAS. Catalyzes all the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Able to elongate saturated acyl chains from 4 to at least 16 carbons. Uses malonyl-CoA but not acetyl-CoA as primer substrate. When expressed in a heterologous system, reveals a bimodal distribution of products, with peaks at C8 and C14-C16. The major product of the reaction (octanoyl-ACP) is required for the lipoylation of essential mitochondrial proteins. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

KAS

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Mutations

Mutation(s) distribution

Mutations table

Search Mutation