FEATURES

FAMILY

DESCRIPTION

Also known as PCO2_ARATH, PCO2, HUP43. Catalyzes the oxidation of N-terminal cysteine residues (N-Cys), thus preparing the protein for N-end rule pathway-mediated proteasomal degradation, upstream of the N-end rule enzymes ATE1, ATE2 and PRT6 (PubMed:24599061, PubMed:29848548, PubMed:33207269). Controls the preparation of the group VII ethylene response factor (ERF-VII) proteins for degradation via the 26S proteasome N-end rule pathway (PubMed:24599061, PubMed:29848548, PubMed:33207269). Acts as an oxygen sensor that controls the stability of ERF-VII proteins, which are stabilized in flooding-induced hypoxia, and regulate transcriptional adaptation to these adverse conditions (Probable) (PubMed:29848548). Not active on Cys located inside or at the C-terminus of a peptide (PubMed:24599061). Acts redundantly with PCO1 to repress the anaerobic response (PubMed:24599061).

EXTERNAL LINKS

PCO2

Mutations

Mutation(s) distribution

Mutations table