FEATURES

DESCRIPTION

Also known as BRAT_DROME, brat. A NHL-domain family protein that functions a translational repressor to inhibit cell proliferation (PubMed:11274060). Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR (PubMed:11274060). Probably recruited by other proteins to repress translation of other mRNAs in other tissues (PubMed:11274060). Involved in the regulation of ribosomal RNA synthesis and cell growth (PubMed:11807032). Participates in abdominal segmentation and imaginal disk development (PubMed:11274060). During neuroblast division, segregates asymmetrically and inhibits self-renewal of one of the two daughter cells (PubMed:16564014). Together with the asymmetrically segregating transcription factor prospero ensures that the daughter cell will stop growing, exit the cell cycle, and differentiate into neurons possibly by modulating the function of dm in ganglion mother cells (GMC) (PubMed:11807032, PubMed:16564014). Restrics developmental potential of type II intermediary neuronal progenitor (INP) cells playing a role in proliferation and maturation of the neuroblasts (PubMed:24550111, PubMed:14561773, PubMed:22143802, PubMed:18342578). Interacts with nos and pum (PubMed:11274060). Acts via the formation of a quaternary complex composed of pum, nos, brat and the 3'-UTR mRNA of hb (PubMed:11274060). Not recruited by nos and pum to cyclin B 3'-UTR mRNA (PubMed:11274060). Might interact with mira; the interaction seems to be important for brat localization during mitosis (PubMed:16564014).

EXTERNAL LINKS

brat

Brain tumor protein

brat

Molecular Synopsis