FEATURES

FAMILY

DESCRIPTION

Also known as ASCC3_HUMAN, ASCC3, HELIC1, RQT2. 3'-5' DNA helicase involved in repair of alkylated DNA (PubMed:22055184). Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016). Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:12077347, PubMed:29144457, PubMed:29997253). Functions as scaffolding subunit that interacts directly with both ASCC1 and ASCC2 (PubMed:29144457, PubMed:29997253). Interacts directly with ALKBH3, and thereby recruits ALKBH3 to the ASCC complex (PubMed:22055184, PubMed:29144457). Part of the ASC-1/TRIP4 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Identified in the RQT (ribosome quality control trigger) complex, that contains ASCC2, ASCC3 and TRIP4 (PubMed:32099016). Interacts with ASCC2 (PubMed:32099016). Interacts with TRIP4 (PubMed:32099016). Interacts with ZCCHC4 (PubMed:31799605). Interacts with ZNF598 (PubMed:28757607). Interacts with RPS3 (PubMed:28757607). Associates with ribosomes (PubMed:32099016).

EXTERNAL LINKS

ASCC3

Mutations

Mutation(s) distribution

Mutations table