FEATURES

DESCRIPTION

Also known as PLCD3_HUMAN, PLCD3, KIAA1964. Hydrolyzes the phosphatidylinositol 4, 5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLCD3

1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-3

PLCD3

Molecular Synopsis