FEATURES

DESCRIPTION

Also known as ZGPAT_HUMAN, ZGPAT, GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP. Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis., Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. Interacts with CHD4/Mi-2; the interaction is direct.

Also known as ZGPAT_HUMAN, ZGPAT, GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP. Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcri ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ZGPAT

Zinc finger CCCH-type with G patch domain-containing protein

ZGPAT

Molecular Synopsis