FEATURES

FAMILY

DESCRIPTION

Also known as CELF5_HUMAN, CELF5, BRUNOL5. RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CELF5

CUGBP Elav-like family member 5

CELF5

Molecular Synopsis