FEATURES

FAMILY

DESCRIPTION

Also known as RN152_HUMAN, RNF152. E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937). Interacts with RRAGA (inactive GDP-bound form); stimulated by amino acid starvation (PubMed:25936802). Interacts with SEC16A (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNF152

E3 ubiquitin-protein ligase RNF152

RNF152

Molecular Synopsis